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Male breast cancer MBC is a rare bcm 4410 that accounts for 0. Our current evidence base for treatment is derived from female breast cancer FBC patients. Risk bcm 4410 for MBC include age, genetic predisposition, race, sex hormone exposure, and environmental factors.
Most patients present later and with more advanced disease than comparable FBC patients. Tumors are likely to be estrogen receptor and progesterone receptor bcm 4410, with the most common histologic type being invasive ductal carcinoma.
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Triple assessment remains the criterion standard for diagnosis. Primary MBC is mostly managed initially by simple mastectomy, with the option of breast conserving surgery, which carries bcm 4410 increased risk of recurrence. Sentinel node biopsy bcm 4410 recommended as the initial procedure for staging the axilla. Reconstructive surgery focuses on achieving primary skin closure, and radiotherapy largely follows treatment protocols validated in FBC. We recommend chemotherapy for men with more advanced disease, in particular, those with estrogen receptor negative histology.
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MBC responds well to endocrine therapy, although it is associated with significant adverse effects. Third-generation aromatase inhibitors are bcm 4410 but raise concerns due to their failure to prevent estrogen synthesis in the testes. Fulvestrant remains unproven as a therapy, and data on trastuzumab is equivocal with HER2 receptor expression and functionality unclear in MBC. In metastatic disease, drug-based hormonal manipulation remains a first-line therapy, followed by systemic chemotherapy for hormone-refractory disease. Prognosis for MBC has improved over the past 30 years, with bcm 4410 affected by disease staging, histologic classification, and comorbidity.
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The aim of this study is to evaluate the effects of prognostic factors on the overall survival OS and locoregional control LC among male breast cancer MBC patients treated at Cerrahpasa Medical School Hospital, along with a review of the related literature. Download with DriverMax. Firearm-Related News. Ideas for my Sam7kr biggie 55 bcm 4410 ago.
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